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Difficulty falling asleep (sleep onset insomnia) Trouble falling asleep within 20-30 minutes of lying down is the most commonly reported sleep problem on tirzepatide

Similar to the natural GLP-1 peptide, GLP-1R agonists such as exendin-4 have likewise been shown in animal models and humans to require glucose concentrations above basal levels to promote insulin secretion

For most users, no

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Ismail C.A.N., Suppian R., Aziz C.B.A., Long I

This is one of the most common questions, and the short answer is: only under a clinicians decision and supervision