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The currently available GLP-1 receptor agonists are derived either from the exendin-4 molecule (exenatide) or from the human GLP-1 scaffold (liraglutide, dulaglutide, and semaglutide)

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Moreover, it is known that in arteriosclerosis model mice, GLP-1 signaling increases the expression of eNOS which leads to the dilatation of blood vessel 8

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