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This piles on the stack of possible indications for the drug, which was just approved for cardiovascular disease prevention in those with obesity in March of this year

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Managing these side effects might involve lowering the dose, increasing the dose more gradually, splitting the dose, taking the medication with food, or combining spironolactone with a combined oral contraceptive to stabilize menstrual cycles and reduce breakthrough bleeding

It often happens because appetite drops, calorie intake decreases, and the body may temporarily conserve energy in response to eating less