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Even more telling, gastrointestinal side effects causing treatment discontinuation were lower with tirzepatide (2.7%) than semaglutide (5.6%)

Adding a GLP-1 drug could potentially heighten that risk in certain scenarios: the medication will make your pancreas secrete insulin when you do ingest carbs, and simultaneously it suppresses glucagon (the hormone that tells your liver to release glucose)

Conversely, evening or bedtime administration may benefit some patients who find that sleeping through the initial hours after injection helps them avoid or minimize awareness of nausea

GLP-1 receptor agonists (GLP-1RAs) like liraglutide and semaglutide, as well as the dual GLP-1 and gastric inhibitory polypeptide (GIP) agonist tirzerpatide are a class of medications that were historically designed to treat type 2 diabetes

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Diabetes 60 , 23972406 (2011)