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[1] [24] If outside these windows, skip the missed dose and resume the regular schedule

According to FDA prescribing information, these include: Nausea (occurring in 1544% of patients depending on the specific agent and dose) Vomiting (524% of patients) Diarrhea (821% of patients) Constipation (1024% of patients) Abdominal pain or discomfort (514% of patients) These symptoms typically emerge during dose initiation or escalation and often diminish over several weeks as the body adapts

In fact, mice with hepatocyte-specific DPP-4 knockdown have a significant reduction in serum DPP-4 activity and reduced adipose tissue inflammation, insulin resistance, and glucose intolerance [20]

Dosing frequency and medication adherence in chronic disease

doi: 10.1007/s42000-018-0038-0 125 HunterKHolscherC

Artunc-Ulkumen B, Pala HG, Pala EE, et al