glp 1 glucagon dual receptor agonist Design of novel Xenopus GLP-1-based glucagon-like peptide (GLP-1)/glucagon agonists Targeting GLP-1, GIP & GCG
Description
It's what's called a "stereoisomer" of fructose, the sugar found in many fruits and vegetables
Gabery S, Salinas CG, Paulsen SJ, Ahnfelt-Rnne J, Alanentalo T, Baquero AF et al
The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta-analysis
In animal studies, GLP-1 drugs were found to cause thyroid C-cell tumors
In mice suffering from non - alcoholic fatty liver disease (NAFLD), liraglutide significantly elevated the abundance of Akkermansia , Romboutsia , and specific members of Bacteroidales, while reducing that of Klebsiella , Anaerotruncus , Bacteroides , and several taxa within the Lachnospiraceae and Ruminococcaceae families ( Firmicutes (e.g., Lachnospiraceae , Clostridiales ) and increased beneficial taxa like Verrucomicrobia and Oscillospiraceae (Madsen et al., 2019)
The dataset will be made available to the pharmaceutical community to help with drug discovery and development
