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Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]
DPP-4 cleaves GLP-1 (7-36amide) and GLP-1 (737) at the N-terminal dipeptide to generate GLP-1 (9-36amide) or GLP-1 (937), low affinity ligands for the GLP-1 receptor [[185], [186], [187], [188]]
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Complement your tirzepatide regimen with a balanced diet, regular exercise, and consistent medical supervision for the best results
