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Confusion grows when trial data, real-world experiences, and medical advice seem to contradict each other

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Nature medicine 28: 20832091

The genes downregulated with semaglutide were significantly enriched in SMAD3 transcription factor motifs, an effector of canonical TGF signalling, as well as ZNF322 and NFY motifs, transcription factors responsive to noncanonical TGF signalling, consistent with the semaglutide-induced decrease in TGF signalling also observed in cardiac myocytes and fibroblasts

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