retatrutide osteoarthritis the wonder drug: What's Established, What's Plausible, What's Still a Hypothesis — WellFounded - Founders Health & Concierge Performance Medicine Retatrutide Cuts Knee OA Pain

Ridha Z et al, Aesthetic Surgery Journal 44(11):NP809-NP818, PMID 38874170) describes GLP-1 receptors on adipose-derived stem cells (ADSCs) and fibroblasts in skin, and proposes that activation of these receptors may reduce protective cytokine production from ADSCs, increase oxidative stress on neighboring fibroblasts, reduce ATP production through altered glucose uptake, and indirectly reduce local estrogen production from dermal white adipose tissue

In other words, the liver was making more cholesterol even while circulating LDL was falling

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several preclinical studies have reported its potential to decrease seizure activity

Retatrutide is not yet available through pharmaceutical channels