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The Downsides of Semaglutide While semaglutide and other GLP-1 RA medications can have many of the positive side effects mentioned above, there are negative side effects that are important to consider as well

C., DiMarchi, R

The body may break down muscle tissue along with fat for energy

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GLP-1s should only be used under the supervision of a licensed healthcare provider because they may cause gastrointestinal side effects, gallbladder disease, and, rarely, pancreatitis or thyroid C-cell tumors

3,4 Strengths of these findings are that the authors analyses did not include patients with comorbidities, namely metabolic disorders or cardiovascular disease
