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Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig

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Food and Drug Administration (FDA) approved Wegovy (semaglutide) for reducing the risk of major cardiovascular events, heart attack, stroke, or death, in adults with obesity and existing cardiovascular disease

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LEPR, leptin receptor