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Rosenstock J, Wysham C, Fras JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Massabrook N Saturday Night Live Mocks Ozempic In Oscars Red Carpet Cold Open: I Guess Everyone In Hollywood Has Diabetes!

Binding to the GLP-1 receptor (GLP-1R), a G protein-coupled receptor (GPCR) widely expressed throughout the body, GLP-1 enhances glucose-dependent insulin secretion and suppresses glucagon, thereby supporting stable glycemia

It is well known that increased glutamate levels are associated with increased neuronal activity, leading to glutamate-induced excitotoxicity via reactive oxygen species (ROS) production [65, 66]