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According to a clinical primer published in the American Heart Association journal Circulation, semaglutide has been associated with lean mass making up a large share of total weight lost, by some trial estimates approaching 40 percent, and tirzepatide has shown a similar pattern at roughly a third of weight lost

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In rats, several studies have shown that native GLP1 administered intraperitoneally (i.p.) requires intact vagal afferents to cause satiation, that is, to reduce meal size (Ruttimann et al., 2009)

Insulin glargine (U-100)/lixisenatide: Insulin glargine/lixisenatide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2D

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Statements Conflict of interest Within the last 36 months, FK has served on scientific advisory panels and/or been part of speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gubra, MedImmune, MSD/Merck, Mundipharma, Norgine, Novo Nordisk, Sanofi and Zealand Pharma