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The mean percent change in body weight from the obesity cohort from baseline to 52 weeks ranged from 12.3% to 16.2% (95% CI, 15.0 to 9.7) to 16.2% (95% CI, 18.9 to 13.5)

Figure 2 Pharmacokinetics The pharmacokinetics in healthy volunteers and patients with T2D are comparable (57)

Despite these limitations, this early analysis provides timely insight into who is receiving oral semaglutide for obesity immediately following approval and demonstrates the value of real-world data for monitoring new drug uptake in near real time

Current practice in the perioperative management of patients with diabetes mellitus: a narrative review

Since IR is an important risk factor for the development of T2DM, the relatively lower IR could be a protective factor against the risk of developing T2DM in PWS patients, which is common in adults but rarely develops in childhood