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But when metabolic health is off-track, it can lead to problems like high blood sugar levels and excess weight

And in blood vessels that are already less flexible or have cholesterol plaques, reintroducing estrogen in the form of hormone replacement therapy can increase the force and speed of blood flow with each heartbeat, sometimes causing a plaque in a vessel to break off and raising the risk of serious problems like heart attack, stroke, or blood clots, says Chervenak

This impact stems from its effect on the glucagon pathway, which instructs the liver and fat cells to emit stored energy

Stay alert for dizziness, extreme fatigue, or heart palpitationsthese signal electrolyte imbalances requiring medical attention

This may reduce calorie intake and support weight loss when combined with nutrition changes, physical activity and medical oversight

If there are no side effects and that dose is effective, continue with that strength and dose