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Hartmann P, American Journal of Physiology Gastrointestinal and Liver Physiology (Vol 329, Issue 6, Dec 1, 2025, pp G680G695)

LOD calculation: Typically mean blank signal + 3 standard deviations
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Retatrutide is a GGG tri-agonist that targets GLP-1 and GIP receptors, akin to standard GLP-1 agonists, but also uniquely activates the glucagon receptor
Unlike GLP-1 receptor agonists, which primarily enhance insulin secretion and satiety, amylin analogues more directly suppress hunger and promote fullness through central nervous system pathways