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Description
Protocols do not run forever
Lincoff A
Even though lower doses are presumably safer, using them would still require a new pre-IND safety justification, dose-range toxicology studies, and possibly a new manufacturing lot release. That would add ~12 years of delay
There is no single right answer that applies to everyone at every phase
However, the types of side effects are similar, and most are manageable with proper dose titration
Can Mounjaro side effects be permanent
