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As addiction researcher Lorenzo Leggio summarized in Nature Medicine in 2023: promising but unproven. 25 Semaglutide-specific randomized trials for alcohol use disorder are underway but have not yet reported their primary outcomes

248,249 It is involved in various chronic diseases

"This softens expression lines that can look more prominent after weight loss," she says

And in 2025, Wegovy also received FDA accelerated approval for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis, underscoring that these medications can impact disease processes well beyond body weight alone

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A basic multivitamin can also help fill some potential gaps