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This dose should be maintained for at least four weeks to assess tolerance and initial therapeutic response before considering further dose escalation

However, current clinical trials have not shown a significant difference in side effect rates between GIPR/GLP-1R dual agonist and GLP-1RA alone

Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population

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Second-generation oral semaglutide, whose bioavailability and safety have been significantly improved by the application of new excipients and formulation optimization, but its gastrointestinal side effects are still obvious (Nielsen et al., 2025)

The GLP-1 receptor activation reduces appetite and slows gastric emptying, which helps control calorie intake