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The initial muscle loss seen with GLP-1 RA treatment as well as the ongoing replacement of muscle with fat with treatment cycles involving treatment interruptions can result in unfavorable changes in body composition in patients with obesity that can have profoundly negative repercussions, and can exacerbate obesity-related metabolic and health concerns 14,15,16

Yes, Zepbound is approved for weight loss

One positive thing that typically stops when you discontinue the medication: the side effects, mainly gastrointestinal discomfort like nausea, says Matthew Hayes, a psychiatry professor at the Perelman School of Medicine at the University of Pennsylvania who studies neural signaling pathways in obesity

Tirzepatide, the active ingredient in Zepbound, was found to have similar effects during the SURMOUNT-1 trial

Most insurance plans cover GLP-1s when they are used to treat diabetes, so those patients can usually avoid the roughly $1,000 monthly price tag of the medications

Mounjaro and Zepbound are given as subcutaneous injections