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While it is not strictly unsafe, people with a history of diverticulitis should be closely monitored by their healthcare provider when starting GLP-1 medicines like Ozempic

10.1038/s41419-017-0217-y [DOI] [PMC free article] [PubMed] [Google Scholar] 47.Gudbergsen H, Henriksen M, Waehrens EE, Overgaard A, Bliddal H, Christensen R, Boesen MP, Knop FKK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard C, Bartels EM, Ellegaard K, Heitmann BL, Kristensen LE (2019) Effect of liraglutide on body weight and pain in patients with overweight and knee osteoarthritis: protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial

We started with GLP-1s like WEGOVY, have progressed to GLP-1 + GIPR targeting agents like ZEPBOUND, and are nearing entry of GLP-1 + GIPR + Glucagon (Lillys retatrutide)

Not everyone reacts in the same way to GLP-1 injections

We further propose that progression from a nave stem cell state to a state primed for differentiation relies on loss of SYGL-1 and LST-1, which in turn relieves FBF target RNAs from repression

Avoid intense sweetness, which many GLP-1 users report triggers or worsens nausea
