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For Wegovy (higher-dose semaglutide for weight management), rates were higher, affecting approximately 29.3% of patients across the STEP clinical trials, with most cases occurring during dose escalation phases

The mediating role of obesity in the development of depression in individuals with diabetes: a population-based study from NHANES 20052014

That profile suits patients who want a lower-cost oral option and accept that results depend heavily on how they eat

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But semaglutide is expensive, costing approximately $1,000 to $1,350 per month without insurance, and no lower-cost generics are currently available

Some people with high baseline body weight or metabolic sensitivity see meaningful results even at low doses