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Description
World of Obesity Atlas, World Obesity, 2023

POMC is processed into alpha- melanocyte-stimulating hormone (-MSH) , which binds to melanocortin receptors and exerts anorexigenic effects
Adding an early dose creates a higher absolute peak than the same timing adjustment at a lower dose

Patients should be advised to eat smaller, more frequent meals, avoid high-fat foods, and stay well-hydrated

In Phase 1 studies, survodutide was generally well tolerated, with no significant safety or tolerability issues observed in either healthy individuals with overweight or obesity [87, 88]

Preprint at medRxiv (2023)