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Patients and clinicians must therefore rely on theoretical considerations, individual patient factors, and clinical judgment

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This distinction is particularly important given the wellestablished bidirectional relationship between diabetes and depression, wherein poor glycaemic control can exacerbate depressive symptoms, and depression can impair diabetes selfmanagement

Avoid trigger foods, which may vary from person to person

In animal models of neurodegenerative diseases, it has been demonstrated that administration of GLP-1RAs can result in the improvement of mitochondrial stability