can glp 1 hurt your kidneys GLP-1 receptor agonists and next-generation metabolic hormone therapies in chronic kidney disease Renoprotective mechanisms of glucagon-like peptide-1

The result: Increased glucose-dependent insulin secretion Reduced glucagon release Better control of fasting & postprandial glucose Weight-neutral therapy with minimal risk of hypoglycemia A simple yet effective mechanism that plays a powerful role in modern diabetes management

Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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More recent evidence is expanding their benefits to heart failure with preserved ejection fraction and clinically important renal outcomes in patients with and without diabetes