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Healthy fats are still useful, but large amounts of fried foods, heavy cream, greasy meals, or big servings of nut butter may feel uncomfortable for some GLP-1 users

Data Extraction and Synthesis Researchers used a systematic yet personalized method to extract data from each study

doi: 10.1001/JAMAINTERNMED.2023.6663 92 DaoKShechtmanSWeber-SchoendorferCDiav-CitrinOMuradRHBerlinMet al

High-fat, high-calorie diets can overwhelm the appetite-suppressing effects of GLP-1 therapy

doi:10.1001/jama.2020.14590 4

GLP-1 and Its Receptor: From Gut Peptide to Central Nervous System (CNS) Signaling GLP-1 is an incretin hormone produced primarily in the intestinal L-cells and, to a lesser extent, by preproglucagon-expressing neurons in the NTS of the brainstem [3,9]