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Evidence suggests GLP-1 therapies may modestly lower blood pressure while improving cardiometabolic risk in patients with diabetes and hypertension.

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This suggests that GLP-1R agonism can reduce ethanol-mediated hepatotoxicity despite continued ethanol consumption and elevate blood alcohol levels.

The incretin effect is defined as the higher stimulation of insulin secretion obtained when glucose is administered orally than intravenously, under similar plasma glucose levels