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15, 16 GLP-1, endogenously produced in the L-cells of the distal ileum and colon, modulates appetite leading to decreased food intake and thus body weight

But tiredness might occur during a weight loss plan for various reasons

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Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow
After 52 weeks of once weekly Zepbound (10 or 15 mg) or placebo, participants on Lillys drug experienced a statistically significant and clinically meaningful reduction in apnea or hypopnea events

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