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Both medicines have been approved in the US, but not yet in the Netherlands or the rest of the EU

Important: Going below 1,200 calories/day (women) or 1,500 calories/day (men) risks muscle loss, nutritional deficiency, and metabolic slowdown even if the deficit looks mathematically right on paper

Suppresses Glucagon Blocks glucagon, a hormone that raises blood sugar

only the FDA has enforcement authority Novo could potentially sue the FDA, but not Hims, for failure to enforce the law Novo Nordisk has used aggressive legal tactics to defend its patents (discussed more below), but it would not be able to sue Hims directly for perceived violations of the Food, Drug, and Cosmetics Act

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The added glucagon receptor activity is one reason researchers are studying whether retatrutide may produce different metabolic and weight-loss effects