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Once inside, they: Reduce neuroinflammation (inhibit NFB, microglial activation) Boost synaptic plasticity (enhance neuron connectivity) Improve glucose uptake (support brain energy metabolism) Local GLP-1 from neurons likely doesnt drive these effectspharmacological action dominates. | 10 comments on LinkedIn

The glucagon-like peptide-1 receptor (GLP-1R) plays a central role in metabolic regulation and is a major therapeutic target for obesity and diabetes

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The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke
