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Trmper A, Trmper K, Trusheim H, Arnold R, Gke B, Hrsch D
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The incidence of nausea for most GLP-1RA drugs was significantly higher than that for placebo, particularly for Orforglipron and Exenatide, with relative risks (RR) of 10.1 and 7, respectively

Side effects drive medication switching

Where semaglutide activates only GLP-1 receptors, tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors
