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The SURMOUNT-1 trial showed tirzepatide at 5 mg producing 7.6 kg of weight loss at 40 weeks

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Can fasting combined with GLP-1 cause muscle loss or metabolic slowdown

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Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, et al

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Since its discovery in the periphery, the presence of PPG, GLP-1 and its receptor GLP-1R has also been reported in the central nervous system

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Other incretin projects : Lilly acquired Protomer Technologies in late 2024 specifically to get access to novel glucagon/GLP-1 peptides and oral incretins

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In a recent NOTW, I shared what I believed to be the three reasons behind the weakness (in relevance order): The narrative around oral GLP-1s Schotts weak FY 2026 guidance (shared early in December) Stevanatos low float (80% or so remains in the hands of the Stevanato family) #3 is what it is and we cant do much about it

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