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These modifications extend plasma half-life and enable once-weekly

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* Regulatory Focus: The DCGI is maintaining strict oversight, ensuring these treatments remain prescription-led medical solutions rather than "lifestyle" products

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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor