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Cell Metabolism, 27(4), 740756
T., Bloom, F
Available from: [PMC free article] [PubMed] 70.Mafham M, Preiss D
This tolerance development explains why side effects are most prominent during treatment initiation and dose escalation but decline substantially with continued use
Research suggests starting at lower doses and increasing every 4-8 weeks produces the best balance of tolerability and effectiveness
Side effects are managed through gradual titration and ongoing monitoring rather than abrupt dosing changes
