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Gradual dose escalation of GLP-1 medications, following FDA-approved titration schedules, helps minimize gastrointestinal side effects that may indirectly contribute to muscle symptoms through reduced intake and activity

-Helical content for soluble (i.e., nonaggregated) samples was estimated using the mean residue ellipticity value at 222 nm (MRE 222 ), which was calculated as follows where m 222 0 is the CD signal in mdeg (machine units) at 222 nm, l is the cuvette path length in cm, c is the sample concentration in mol L 1 , and n is the number of amino acid residues