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Keywords: type 2 diabetes, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide Introduction: The Incretin Effect in Health and Disease The gastrointestinal system has an intricate pathway of hormones that are released from the gut lining upon ingestion of food and regulate glucose metabolism and appetite

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In athymic mice, 63% of exendin-4-treated mice achieved graft function compared with 21% of untreated mice (p = 0.033) in the short-term study

As we expected, either GLP-1R blockade or PKA inhibition partially eliminated the protective effects of the combined therapy on endothelial function

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GLP-1 and exendin-4 show a similar nM affinity while glucagon, secretin, VIP and GLP-2 have at least a hundred times lower affinity for the GLP-1 receptor