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But it almost certainly reduces the gastrointestinal rebound effects that some researchers report after abrupt cessation, including paradoxical increases in appetite, changes in bowel habits, and blood sugar fluctuations

Back Finkelstein, EA, Trogdon, JG, Cohen, JW (2009) 'Annual medical spending attributable to obesity: payer-and service-specific estimates', Health Affairs , 28/5, w82231

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doi: 10.3389/fnsyn.2026.1869086 Received 29 April 2026 Revised 14 May 2026 Accepted 15 May 2026 Published 04 June 2026 Volume 18 - 2026 Edited by Ajeet Kumar, Washington University in St