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This approval for Ozempic allows us to more broadly address conditions within cardiovascular-kidney-metabolic syndrome, which affects millions of adults and could have serious consequences if left untreated," said Anna Windle, PhD, Senior Vice President Clinical Development, Medical & Regulatory Affairs at Novo Nordisk

45 The treatment policy (primary) estimand assessed effects regardless of treatment discontinuation or rescue medication, while the secondary trial product estimand modelled treatment effects in all randomly assigned participants, assuming they had remained on treatment for the duration of the trials, and without initiation of rescue medication

While GLP-1R-decorated nanocarriers can effectively bind and internalize into target cells, quantitative imaging studies indicate that less than 2% of the internalized nucleic acid payload escapes from endosomal compartments into the cytosol