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Intermittent fasting similarly helps utilize fatty acids over glucose for energy when liver glycogen stores are reduced, promoting increased lipolysis, increased hepatic free fatty acid oxidation, decreased lipogenesis, and production of ketone bodies [[95], [96], [97], [98]]

GLP-1 is a hormone your body naturally produces to help regulate blood sugar and appetite

During the transition: Monitor blood glucose more frequently for the first 4 to 6 weeks Expect potential hypoglycemia risk if also taking insulin or sulfonylureas Your provider may need to adjust other diabetes medications A1C improvements may be more pronounced with tirzepatide The SURPASS clinical trials demonstrated that tirzepatide 15 mg reduced A1C by up to 2.58%, compared to semaglutide 1 mg which reduced A1C by 1.86%

Clinical Monitoring and Long-Term Management GLP-1 weight loss therapy is intended as a long-term or indefinite treatment

Coverage requires provider approval, prior authorization, and CMS eligibility rules

Most users begin with a 1-2mg dose during the first month