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Amino acid modifications in the N-terminus and at certain positions in the C-terminus are involved in the resistance to DPP-4 inhibition, thus prolonging its half-life
Diabetes 26 , 480484 (1977)
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Mechanistically, liraglutide normalized oxidative stress, including malondialdehyde and NO, while reduced pro-inflammatory mediators such as IL-6 and COX-2 [12]
