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In the -cell, loss of -arrestin signalling resulted in impaired insulin secretion, whereas it promoted hyperplasia in eWAT and reduced plasma adipokine levels

Now Pfizers public declaration that its at the end of the beginning in entering the GLP1 market marks a pivotal moment: an established pharma giant is moving from watching a niche revolution to competing for mass adoption

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Pro-Survival Signalling in Cardiomyocytes: Myocardial Ischemia Protection In preclinical models of myocardial ischemia, the activation of GLP-1 receptor agonists reduces infarct size by activating powerful pro-survival signalling cascades within the cardiomyocyte