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tirzepatide shortage fda says of popular diabetes, weight-loss drugs resolved FDA says years-long tirzepatide shortage
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Science Snapshot A 2021 study in The New England Journal of Medicine found semaglutide led to 15% weight loss but caused muscle loss in 30% of participants (link)

Suddenly there is a protein version of everything, from chips to pastries to water

Phase 2-3 trials remain

Many patients achieve excellent metabolic and weight outcomes without significant nausea, while others with mild nausea achieve comparable results

If you are starting a GLP-1 receptor agonist whilst also taking insulin or a sulphonylurea, NICE recommends increasing blood glucose monitoring to detect hypoglycaemia early
Results demonstrated dose-dependent MASH resolution without worsening fibrosis in 51.8%, 62.8%, and 73.3% of participants taking 5mg, 10mg, and 15mg doses respectively, versus merely 13.2% with placebo
