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Compounded semaglutide and tirzepatide offer lower-cost alternatives to branded options, while genetic insights can help optimize medication selection for better clinical outcomes and v

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Electronic databases including PubMed, Embase, and Web of Science were searched from inception until August 2025 using keywords such as GLP-1 receptor agonist, diabetic retinopathy, glaucoma, age-related macular degeneration, ocular disease, and neuroprotection. The search focused on identifying preclinical studies, large-scale retrospective cohort studies, and post-hoc analyses of major clinical trials that evaluated the utility and potential mechanisms of GLP-1RAs in ophthalmic diseases

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Its demonstrated efficacy in glycemic control, weight management, and potential cardiovascular benefits makes it a valuable subject for ongoing research in the treatment of T2DM, obesity, and related metabolic disorders