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To reduce the risk of CI, patients should be counseled to maintain adequate hydration while on a GLP-1 RA provided there are no medical contraindications to increased fluid intake

Common side effects: Nausea or vomiting Dry mouth Headache Dizziness Restlessness Insomnia (difficulty sleeping) or changes in sleep patterns Increased sweating Constipation Changes in appetite or weight Tremors or shaking Blurred vision Less common side effects: Rapid heartbeat or palpitations Muscle or joint aches Ringing in the ears (tinnitus) Sexual dysfunction Rare but serious side effects (should be reported to a healthcare professional immediately): Allergic reactions can present with various symptoms, including rash, itching, swelling, severe dizziness, or difficulty breathing

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Liver cancer risk reduction may be partly explained by the antisteatotic and anti-inflammatory effects of GLP-1 RAs in patients with NAFLD or metabolic syndrome (Figure 5)

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