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The most common adverse effects of metformin are gastrointestinal, including diarrhea, nausea, abdominal discomfort, and metallic taste, occurring in up to 30% of patients
Patients with mild (estimated creatinine clearance 50 to 80 mL/min) to severe (estimated creatinine clearance 9) hepatic impairment were included in the trial
This context supports informed conversations but does not predict exact response
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AM = morning
The freeze-thaw cycle can be incredibly destructive
