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High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications

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Ottawa: Precedence Research

Mol Metab (2020) 39:101014

Treatment of acute depression The goals of pharmacological management of acute bipolar depression are to restore euthymia as early as possible (because even untreated depressive episodes resolve spontaneously), prevent a manic/hypomanic switch, and improve psychosocial functioning