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It's meant to "bridge" the gap before a longer-term program that might or might not begin in 2028

Phase 1 and Early Development Phase 1 studies in healthy volunteers established proof-of-concept, demonstrating that retatrutide was well-tolerated and produced dose-dependent effects on appetite, food intake, and body weight with acceptable safety profiles

Coleman RL, Stevens RJ, Retnakaran R, Holman RR

Agnihothri RV, Courville AB, Linderman JD, et al

Orlistat has also been shown to reduce: BMI Waist circumference Cholesterol Low-density lipoprotein (LDL) levels (considered "bad" cholesterol) However, Orlistat might be less effective than other weight-loss medications