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This phenomenon is orchestrated by the enteroendocrine hormones GLP-1 and Gastric Inhibitory Peptide (GIP), both of which concomitantly facilitate insulin secretion (Figure 1)

Whether you're on a GLP-1 medication like Ozempic or Wegovy, or simply looking to support your body's natural appetite hormones through food, what you snack on matters enormously

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These findings suggest that gastrointestinal distension serves as a physiological stimulus for GLP-1 secretion and that this mechanism may be effective in preventing and ameliorating hyperphagic obesity
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