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JAMA Netw Open 2024;7:e2423385.ArticlePubMedPMC 74
This impairment alone could contribute to the pathogenesis of diabetes
The HOMA-IR index decreased from 5.43.9 to 3.52.0 in therapeutic arm only
Elevated cAMP levels subsequently activate protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (RAPGEF4, also known as EPAC2)
Additionally, it remains a highly effective treatment for severe itching (pruritus) caused by allergic skin reactions like hives or contact dermatitis
Int J Epidemiol 48(5):16361649
