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Addictive substances typically cause supraphysiological dopamine release in the nucleus accumbens, reinforcing drug-seeking behaviour

Appetite and cravings may also intensify, leaving clients feeling out of control or discouraged

GLP-1s support weight management by mimicking a hormone naturally produced in the body that regulates appetite

Alternatively, the oral Wegovy pill provides the same active ingredient daily for those avoiding injections, while Foundayo (orforglipron) permits dosing without time restrictions, maximizing flexibility

Emerging evidence suggests that GLP-1R agonists also influence broader reward-related behaviors beyond reduction in food intake

These are generally most pronounced during the dose titration phase and tend to diminish as the body adjusts to treatment